international prognostic scoring system for myelodysplastic syndrome

Introduction

International Scoring System

% blasts in bone marrow	score
< 5	0
5-10	0.5
---	1.0
11-20	1.5
21-30	2.0

karyotype* good intermediate poor

cytopenias** 0-1 2-3

* karyotypes:

good: normal, 5q deletion, 20q deletion

poor: complex abnormalities (>3) or chromosome 7

abnormalities

intermediate: others

** cytopenias

absolute neutrophil count < 1800/uL

hemoglobin < 10g/dL

platelets < 100,000/uL

scoring

risk group	score	Survival < 60	Survival > 60	Leukemia Death
low	0	11.8	4.8	19%
intermediate 1	0.5-1.0	5.2	2.7	30%
intermediate 2	1.5-2.0	1.8	1.1	33%
high	2.5+	0.3	0.5	45%

* Leukemia Death: death due to Leukemia

* Survival: median survival years age < 60 years & > 60 years

risk group	score	Survival < 60	Survival > 60	Leukemia Death
low	0	11.8	4.8	19%
intermediate 1	0.5-1.0	5.2	2.7	30%
intermediate 2	1.5-2.0	1.8	1.1	33%
high	2.5+	0.3	0.5	45%

* Leukemia Death: death due to Leukemia

* Survival: median survival years age < 60 years & > 60 years