laryngopharyngeal reflux (LPR)
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Etiology
- complication of GERD
Clinical manifestations
- hoarseness
- repetitive throat clearing
- excessive pharyngeal mucous
- globus
- voice changes
- duration > 3 months
Diagnostic procedures
- laryngoscopy
- 24 hour esophageal pH monitor (ambulatory)
Differential diagnosis
Management
- proton pump inhibitor (PPI) of no benefit[1]
- acid suppression likely to prevent laryngopharyngeal injury with GERD-associated laryngopharyngeal reflux[2]
- alkaline water (pH >8.0) & a plant-based, Mediterranean diet plus standard reflux precautions no better than PPI[4]
More general terms
Additional terms
References
- ↑ Jump up to: 1.0 1.1 Vaezi MF et al, Treatment of chronic posterior laryngitis with esomeprazole Laryngoscope 2006;116:254 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16467715
- ↑ Jump up to: 2.0 2.1 Roh JL, Lee YW, Park HT. Effect of acid, pepsin, and bile acid on the stenotic progression of traumatized subglottis. Am J Gastroenterol. 2006 Jun;101(6):1186-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16771935
- ↑ Wo JM et al, Double-blind, placebo-controlled trial with single-dose pantoprozole for laryngopharyngeal reflux. Am J Gastroenterol 2006, 101:1972 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16968502
Vaezi MF et al, Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope 2006, 116:254 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16467715 - ↑ Jump up to: 4.0 4.1 Zalvan CH, Hu S, Greenberg B et al A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux. JAMA Otolaryngol Head Neck Surg. Published online Sept 7, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28880991 <Internet> http://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2652893
Kavitt RT Dietary Modifications in the Treatment of Laryngopharyngeal Reflux - WIll "an Apple a Day" Keep the Laryngopharyngeal Reflux Away? JAMA Otolaryngol Head Neck Surg. Published online Sept 7, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28880985 <Internet> http://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2652892