statin therapy in children
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Indications
Adverse effects
- well tolerated (see statin)
Mechanism of action
- decreases total cholesterol & LDL cholesterol similar to adults
- diminishes carotid artery intima thickness in children with familial hypercholesterolemia
References
- ↑ Journal Watch 24(16):127, 2004 Wiegman A, Hutten BA, de Groot E, Rodenburg J, Bakker HD, Buller HR, Sijbrands EJ, Kastelein JJ. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial. JAMA. 2004 Jul 21;292(3):331-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15265847