esmethadone

^[1]

Indications

shows promise as adjunctive treatment for patients with antidepressant tolerance

↑ Guidetti C, Papakostas GI, Pani L et al Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Antidepressant Tachyphylaxis: An Exploratory Post Hoc Analysis From a Phase 3 Randomized Controlled Trial. J Clin Psychiatry. 2025 Oct 6;86(4):24m15748. PMID: https://pubmed.ncbi.nlm.nih.gov/41060071 Clinical Trial. https://www.psychiatrist.com/jcp/esmethadone-rel-1017-major-depressive-disorder-antidepressant-tachyphylaxis-post-hoc-analysis-phase-3-rct/