expansion in situ genome sequencing
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Introduction
microscopy technique can simultaneously sequence an individual cell's DNA & pinpoint the location of proteins inside the cell without breaking open the cell
More general terms
References
- ↑ Ledford H 'Phenomenal' tool sequences DNA and tracks proteins - without cracking cells open. Microscopy technique allows scientists to image how proteins and chromosomes interact in an intact cell. Nature News. 2024. October 10 https://www.nature.com/articles/d41586-024-03276-7
Labade AS, Chiang ZD, Comenho C et al Expansion in situ genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression. bioRxiv [Preprint]. 2024 Sep 26:2024.09.24.614614. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39386718 PMCID: PMC11463693 Free PMC article. Preprint.