donidalorsen
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Indications
- prophylactic treatment for hereditary angioedema
Dosage
- 80 mg subcutaneously every 4 weeks
Adverse effects
- erythema at the injection site
- headache
- nasopharyngitis
* 98% of adverse events were mild or moderate in severity.
Mechanism of action
- antisense oligonucleotide, specifically reduces prekallikrein expression
More general terms
References
- ↑ Lou N Hereditary Angioedema Attacks Reduced With Donidalorsen Prophylaxis. Investigational treatment passes muster in phase III trial MedPage Today May 31, 2024 https://www.medpagetoday.com/allergyimmunology/allergy/110412
Riedl MA, Tachdjian R, Lumry WR et al Efficacy and Safety of Donidalorsen for Hereditary Angioedema. N Engl J Med 2024. May 31 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38819395 https://www.nejm.org/doi/full/10.1056/NEJMoa2402478