Frank-Starling law
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Pathology
- pathology ensues when the normal physiologic range is exceeded, where the increase in ventricular diastolic volume fails to increase the force of ventricular contraction, but rather decreases it such as occurs with left ventricular systolic dysfunction
Physiology
- based on the link between the initial length of myocardial fibers & force generated by contraction
- within a normal physiologic range, the greater the ventricular diastolic volume, the more the myocardial fibers are stretched during diastole & the greater the force of ventricular contraction
- thus ventricular output increases as preload (end-diastolic pressure or volume) increases
References
- ↑ Delicce AV, Makaryus AN Physiology, Frank Starling Law StatPearls [Internet]. Jan 30, 2023 (figure) National Library of Medicine https://www.ncbi.nlm.nih.gov/books/NBK470295/
- ↑ NEJM Knowledge+ (figure) The relationship between preload and end-diastolic volume The Frank-Starling Curves https://knowledgeplus.nejm.org/wp-content/uploads/2021/05/frank_starling_resource.png
