intention-to-treat analysys
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Introduction
Analysis of the results of a randomized controlled trial is based on the initial treatment assignment, not on the treatment eventually received.
- intended to avoid various misleading artifacts
- non-random attrition of participants from the study
- crossover
- simpler because it does not require observation of compliance
- maintains the balance generated in the original randomization process for each treatment group[2]
More general terms
References
- ↑ Wilipedia: Intention-to-treat analysis https://en.wikipedia.org/wiki/Intention-to-treat_analysis
- ↑ 2.0 2.1 NEJM Knowledge+
Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res. 2011 Jul;2(3):109-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21897887 PMCID: PMC3159210 Free PMC article.
Detry MA, Lewis RJ. The intention-to-treat principle: how to assess the true effect of choosing a medical treatment. JAMA. 2014 Jul 2;312(1):85-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25058221 No abstract available.