intention-to-treat analysys

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Introduction

Analysis of the results of a randomized controlled trial is based on the initial treatment assignment, not on the treatment eventually received.

  • intended to avoid various misleading artifacts
    • non-random attrition of participants from the study
    • crossover
  • simpler because it does not require observation of compliance
  • maintains the balance generated in the original randomization process for each treatment group[2]

More general terms

References

  1. Wilipedia: Intention-to-treat analysis https://en.wikipedia.org/wiki/Intention-to-treat_analysis
  2. 2.0 2.1 NEJM Knowledge+
    Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res. 2011 Jul;2(3):109-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21897887 PMCID: PMC3159210 Free PMC article.
    Detry MA, Lewis RJ. The intention-to-treat principle: how to assess the true effect of choosing a medical treatment. JAMA. 2014 Jul 2;312(1):85-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25058221 No abstract available.