intention-to-treat analysys

^[1]^[2]^[3]

Introduction

Analysis of the results of a randomized controlled trial is based on the initial treatment assignment, not on the treatment eventually received.

intended to avoid various misleading artifacts
- non-random attrition of participants from the study
- crossover
simpler because it does not require observation of compliance
maintains the balance generated in the original randomization process for each treatment group^[2]

labeling non-random attrition of participants & crossover as misleading artifacts just meant you did not know how to analyze the data

↑ Wilipedia: Intention-to-treat analysis https://en.wikipedia.org/wiki/Intention-to-treat_analysis
↑ ^2.0 ^2.1 NEJM Knowledge+
Gupta SK. Intention-to-treat concept: A review. Perspect Clin Res. 2011 Jul;2(3):109-12. PMID: https://pubmed.ncbi.nlm.nih.gov/21897887 PMCID: PMC3159210 Free PMC article.
Detry MA, Lewis RJ. The intention-to-treat principle: how to assess the true effect of choosing a medical treatment. JAMA. 2014 Jul 2;312(1):85-6. PMID: https://pubmed.ncbi.nlm.nih.gov/25058221 No abstract available.
↑ Tripepi G, Chesnaye NC, Dekker FW, et al. Intention to treat and per protocol analysis in clinical trials. Nephrology (Carlton). 2020;25:513-517. PMID: https://pubmed.ncbi.nlm.nih.gov/32147926