trimetazidine
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Introduction
Not approved for use in U.S.
Indications
- treatment of angina pectoris in Europe & Russia
- treatment of vertigo, tinnitus
Pharmacokinetics
- 1/2 life 8 hours, 12 hours in the elderly
- most excreted in the urine unaltered
Mechanism of action
- inhibits fatty acid oxidation, shifting metabolism towards glucose oxidation, thus cells more efficient in hypoxic environment
Notes
- Olympic controversy, Russian skater Kamila Valieva tested positive for trimetazidine
- use may give athletes an edge
More general terms
References
- ↑ Yang J, Zhang L, Liu C et al Trimetazidine attenuates high-altitude fatigue and cardiorespiratory fitness impairment: A randomized double-blinded placebo-controlled clinical trial. Biomed Pharmacother. 2019. Aug;116:109003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31125823 Free article https://www.sciencedirect.com/science/article/pii/S0753332219310261
- ↑ Howes L What is trimetazidine and why is it banned in Olympic competition? Chemical ^ Engeineering News. Feb 17, 2022 https://cen.acs.org/analytical-chemistry/forensic-science/trimetazidine-banned-Olympic-competition/100/web/2022/02