intravenous antibiotic therapy
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Adverse effects
- 25% of patients who receive at least 2 weaks of IV antibiotics develop eosinophilia[6]
- only vancomycin associated with excess risk of DRESS[6]
Management
- blood cultures should be drawn prior to initiation of intravenous antibiotic therapy
- all patients on IV antibiotics with intact GI system whose clinical status is improving should be considered for switch to oral therapy[1][2]
- continued inpatient monitoring of stable patients after transition from IV to oral antibiotics does not improve outcomes[1]
- outpatient IV antibiotics may be appropriate for selected patients[1]
- if used for <= 14 days, midline catheters have fewer major complications than PICC[8]
More general terms
References
- ↑ Jump up to: 1.0 1.1 1.2 1.3 Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018.
- ↑ Jump up to: 2.0 2.1 Masterton RG Antibiotic de-escalation. Crit Care Clin. 2011 Jan;27(1):149-62 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21144991
- ↑ Cunha BA. Oral antibiotic therapy of serious systemic infections. Med Clin North Am. 2006 Nov;90(6):1197-222. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17116444
- ↑ Chapman AL. Outpatient parenteral antimicrobial therapy. BMJ. 2013 Mar 26;346:f1585. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23532865
- ↑ Seaton RA, Barr DA. Outpatient parenteral antibiotic therapy: principles and practice. Eur J Intern Med. 2013 Oct;24(7):617-23. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23602223
- ↑ Jump up to: 6.0 6.1 6.2 Blumenthal KG et al. Peripheral blood eosinophilia and hypersensitivity reactions among patients receiving outpatient parenteral antibiotics. J Allergy Clin Immunol 2015 Nov; 136:1288. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25981739
- ↑ Cyriac JM, James E. Switch over from intravenous to oral therapy: A concise overview. J Pharmacol Pharmacother. 2014 Apr;5(2):83-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24799810 Free PMC Article
- ↑ Jump up to: 8.0 8.1 Paje D, Walzl E, Heath M et al. Midline vs peripherally inserted central catheter for outpatient parenteral antimicrobial therapy. JAMA Intern Med 2024 Nov 11; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39527077 PMCID: PMC11555572 Free PMC article https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2825765