Aldurazyme (alpha-L-iduronidase)

Introduction

Tradename: Aldurazyme (FDA approved 2003)

Indications

• mucopolysaccharidosis 1 (Hurler-Scheie syndrome)

Mechanism of action

• enzyme replacement therapy
• hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate

More general terms

• alpha-L-iduronidase (laronidase, Aldurazyme, IDUA)
• metabolic agent (metabolic modifier)