ChiRhoStim (secretin)

Introduction

Tradename: ChiRhoStim

Indications

• diagnosis of Zollinger-Ellison syndrome (ZE syndrome) & pancreatic exocrine disease
• hepatobiliary diseases such as obstructive jaundice

Dosage

• pancreatic function: 1 CU/kg slow IV injection over 1 min
• ZE syndrome: 2 CU/kg slow IV injection over 1 min

Powder for injection: 75 CU (10 mL).

Adverse effects

• uncommon (< 1%)
  • fainting, venous spasm, hypersensitivity

Mechanism of action

• stimulates secretion of bicarbonate-rich pancreatic fluid

More general terms

• secretin (SCT)
• gastrointestinal agent

Additional terms

• secretin receptor; SCT-R (SCTR)
• secretin stimulation test