drug interaction(s) of calcineurin inhibitors with ARBs

^[1]

Drug interactions

coadministration of ACE inhibitor or ARB with aldosterone antagonist associated with risk of hyperkalemia
- risk for severe hyperkalemia is lower with coadministration of sacubitril/valsartan than with enalapril^[1]

↑ ^1.0 ^1.1 Desai AS, Vardeny O, Claggett B et al Reduced Risk of Hyperkalemia During Treatment of Heart Failure With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/ Valsartan Compared With Enalapril. A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. Published online November 14, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27842179 <Internet> http://jamanetwork.com/journals/jamacardiology/article-abstract/2583456
Ezekowitz JA Hyperkalemia, Sacubitril/Valsartan, and Mineralocorticoid Antagonists in Patients With Heart Failure. JAMA Cardiol. Published online November 14, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27842180 <Internet> http://jamanetwork.com/journals/jamacardiology/article-abstract/2583455