USPSTF grade definitions; evidence grade

Classification

• grade A
  • high certainty that benefit is substantial & exceeds risk
  • offer or provide intervention
• grade B
  • high certainty that benefit is moderate & exceeds risk
  • offer or provide intervention
• grade C
  • moderate certainty that benefit is small
  • provide intervention on an individual basis
• grade D
  • moderate-high certainty than intervention is not beneficial or that risks exceed benefits
  • discourage intervention
• grade I
  • evidence is lacking, of poor quality or conflicting rendering uncertainty of the risks vs benefits