selenium deficiency; Keshan disease

From Aaushi
Jump to navigation Jump to search

Etiology

selenium deficiency

Epidemiology

  • Keshan disease observed spreading in 1935 in rural areas of Heilongjiang province in northern China (1st reported in Keshan county)
  • Keshan disease affects mostly children & women of child-bearing age
  • endemic in rural northern China
  • widespread selenium deficiency found in all regions of the brains examined in patients with Huntington's disease[2]

Pathology

Clinical manifestations

Complications

  • may be fatal

Management

More general terms

Additional terms

References

  1. Tungsheng L Selenium in: Chemical & Engineering News, Sept 8, 2003, page 94
  2. 2.0 2.1 2.2 George J Widespread Selenium Deficiency Seen in Huntington's Disease Brains
    Researchers caution about self-medicating MedPage Today October 24, 2023 https://www.medpagetoday.com/neurology/generalneurology/106970
    Scholefield M, Patassini S, Xu J, Cooper GJS. Widespread selenium deficiency in the brain of cases with Huntington's disease presents a new potential therapeutic target. eBioMedicine. 2023 Oct 6:97:104824 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37806287 https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00390-0/fulltext