bremelanotide (Vyleesi)
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Indications
- premenopausal women with acquired, generalized hypoactive sexual desire disorder
Contraindications
- uncontrolled hypertension
- cardiovascular disease
- concurrent use of naltrexone for opioid or alcohol use disorder
Dosage
- injection
- no more than one dose a day or 8 doses a month
- stop treatment at 8 weeks if no improvement in sexual desire or distress
Adverse effects
- nausea often with 1st injection
- darkening of the gums & skin (1%)
- increased blood pressure that usually resolves within 12 hours
Mechanism of action
- activates melanocortin receptors widely expressed in the brain
More general terms
References
- ↑ FDA News Release. June 21, 2019 FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women. https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-hypoactive-sexual-desire-disorder-premenopausal-women