allopurinol/lesinurad (Duzallo)
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Indications
gout (FDA-approved August 2017)
Dosage
- once daily oral dosing
- in the morning with food & water
- stay well hydrated
- drink about 2 L of liquid a day when taking the drug
Tabs:
- lesinurad 200 mg plus allopurinol 300 mg
- lesinurad 200 mg plus allopurinol 200 mg
Adverse effects
- headache
- influenza
- GERD
- increased serum creatinine (generally transient)[2]
Boxed warning: risk for acute renal failure
Mechanism of action
- may diminish serum uric acid more than allopurinol alone
More general terms
Components
References
- ↑ Brooks M FDA Clears First Fixed-Dose Combination Treatment for Gout. Medscape - Aug 21, 2017. http://www.medscape.com/viewarticle/884534
- ↑ 2.0 2.1 2.2 Saag KG, Fitz-Patrick D, Kopicko J et al. Lesinurad combined with allopurinol: A randomized, double-blind, placebo-controlled study in gout patients with an inadequate response to standard-of-care allopurinol (a US-based study). Arthritis Rheumatol 2017 Jan; 69:203. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27564409 Free Article https://onlinelibrary.wiley.com/doi/abs/10.1002/art.39840
Bardin T, Keenan RT, Khanna PP et al. Lesinurad in combination with allopurinol: A randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). Ann Rheum Dis 2017 May; 76:811 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27821644 Free PMC Article https://ard.bmj.com/content/76/5/811