allopurinol/lesinurad (Duzallo)

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Indications

gout (FDA-approved August 2017)

Dosage

  • once daily oral dosing
    • in the morning with food & water
    • stay well hydrated
    • drink about 2 L of liquid a day when taking the drug

Tabs:

Adverse effects

Boxed warning: risk for acute renal failure

Mechanism of action

More general terms

Components

References

  1. Brooks M FDA Clears First Fixed-Dose Combination Treatment for Gout. Medscape - Aug 21, 2017. http://www.medscape.com/viewarticle/884534
  2. 2.0 2.1 2.2 Saag KG, Fitz-Patrick D, Kopicko J et al. Lesinurad combined with allopurinol: A randomized, double-blind, placebo-controlled study in gout patients with an inadequate response to standard-of-care allopurinol (a US-based study). Arthritis Rheumatol 2017 Jan; 69:203. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27564409 Free Article https://onlinelibrary.wiley.com/doi/abs/10.1002/art.39840
    Bardin T, Keenan RT, Khanna PP et al. Lesinurad in combination with allopurinol: A randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). Ann Rheum Dis 2017 May; 76:811 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27821644 Free PMC Article https://ard.bmj.com/content/76/5/811