MT-ND4 gene mutation

Pharmacology

• investigational intravitreal gene therapy lenadogene nolparvovec (Lumevoq)

Clinical significance

• defects in MT-ND4 are a cause of
  • Leber hereditary optic neuropathy
  • Leber optic atrophy & dystonia
  • MELAS syndrome

More general terms

• gene mutation testing; gene mutation analysis

Additional terms

• NADH dehydrogenase subunit-4