protein MYH16; myosin heavy chain 16 pseudogene protein; myosin heavy polypeptide 5 (MYH16, MYH5)

Function

• loss of function in masticatory muscles contraction suspected for its homologs in dog & apes
• biological significance unclear since it lacks most of the domains important for the function of myosins

Structure

• belongs to the TRAFAC class myosin-kinesin ATPase superfamily, myosin family

Expression

• specifically expressed in muscles of the head, including temporalis & tensor veli palatini

Comparative biology

• an inactivating mutation in MYH16 probably appeared 2.4 million years ago in a hominid ancestor
• the inactivation & its correlation with evolution of the skull & cranial capacity in hominids is not clear

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H6N6.html