drug interaction(s) of sofosbuvir with amiodarone
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Drug interactions
- combination of sofosbuvir with amiodarone associated with 9 cases of symptomatic bradycardia with 1 fatal cardiac arrest[1]
More general terms
References
- ↑ 1.0 1.1 Gilead Sciences, Inc. 3/20/2015 IMPORTANT DRUG WARNING Subject: Serious and Life-Threatening Cases of Symptomatic Bradycardia as well as one Case of Fatal Cardiac Arrest Reported with Coadministration of Amiodarone with either Harvoni<TM> (ledipasvir and sofosbuvir fixed-dose combination) or with Sovaldi<TM> (sofosbuvir) in combination with another Direct Acting Antiviral. http://freepdfhosting.com/47b90580b3.pdf
- ↑ FDA Safety Alert, March 24, 2015 Hepatitis C Treatments Containing Sofosbuvir in Combination With Another Direct Acting Antiviral Drug: Drug Safety Communication - Serious Slowing of Heart Rate When Used With Antiarrhythmic Drug Amiodarone. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm439662.htm