Michaelis-Menton kinetics

Introduction

Model in which an enzyme binds substrate to reversibly form an intermediate enzyme-substrate complex which then dissociates to form product (or regenerates substrate.

       k1         k3
E + S  ->    ES   ->    E  +  P
      <-
       k2

E = enzyme, S = substrate, P = product

S >> E, E is not an allosteric enzyme

Also see Michaelis constant

In this model, reaction rate reaches a maximum velocity (Vmax) when substrate saturates the enzyme (ES >> E)

Additional terms

• Michaelis Constant