multigene testing; expression profile

^[1]^[2]^[3]^[4]

Indications

panels are available that screen for mutations in up to 30-70 genes^[1]^[2]; the problem becomes how to interpret the results
Guardant360 test
- targets 70 genes
- sensitivity & specificity of detecting advanced cancer from blood specimen is 78-86% compared with tumor biopsy, dependent upon tumor type; specificity is 98% if samples collected within 6 months of each other^[2]
CancerSEEK^[3]
- targets 16 genes + 8 proteins
- machine-based learning analyzes data

↑ ^1.0 ^1.1 Orciari Herman A, Fairchild DG, Di Francesco L Multigene Testing Opening a Can of Worms Physician's First Watch, Sept 24, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
↑ ^2.0 ^2.1 ^2.2 Zill OA et al Somatic genomic landscape of over 15,000 patients with advanced-stage cancer from clinical next-generation sequencing analysis of circulating tumor DNA. J Clin Oncol 34, 2016 (suppl; abstr LBA11501) http://abstracts.asco.org/176/AbstView_176_171265.html
↑ ^3.0 ^3.1 Castellino AM CancerSEEK: Blood Test That Detects Eight Common Cancers Medscape - Jan 18, 2018. https://www.medscape.com/viewarticle/891491
Cohen JD, Li L, Wang Y et al Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science. Jan 18, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29348365 <Internet> http://science.sciencemag.org/content/early/2018/01/17/science.aar3247
↑ ^4.0 ^4.1 Medical Knowledge Self Assessment Program (MKSAP) 19. American College of Physicians, Philadelphia 2021