recombinant factor IX Fc fusion protein (Aprolix)

Indications

• treatment of hemophilia B

Contraindications

• hypersensitivity to components

Pregnancy category: C

Dosage

• prophylaxis
  • start with at least 1 week between infusions
• minor to moderate bleeding
  • every 48 hours as needed
• major bleeding
  • consider repeat dose in 6-10 hours, then
  • every 24 hours for 3 days, then
  • every 48 hours until healing is complete

lyophilized powder in single use vials containing 500, 1000, 2000, or 3000 IU of factor IX

Adverse effects

• common (> 1%)
  • headache, oral paresthesia

More general terms

• coagulation factor IX
• recombinant protein; chimer
• fusion protein