Procollagen galactosyltransferase 2; collagen beta(1-O)galactosyltransferase 2; glycosyltransferase 25 family member 2; hydroxylysine galactosyltransferase 2 (COLGALT2, C1orf17, GLT25D2, KIAA0584)

Function

• has a beta-galactosyltransferase activity
• transfers beta-galactose to hydroxylysine residues on collagen

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] =

UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen]

Kinetic parameters:

• KM=33.5 uM for UDP-galactose

Structure

• belongs to the glycosyltransferase 25 family

Compartment

• endoplasmic reticulum lumen (putative)

Expression

• expressed in brain & skeletal muscle

Notes

• has no glucosyltransferase activity

More general terms

• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23127
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23127
• UniProt: http://www.uniprot.org/uniprot/Q8IYK4.html