basic salivary proline-rich protein 1; salivary proline-rich protein; contains: proline-rich peptide II-2; basic peptide IB-6; peptide P-H (PRB1)

Function

• proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly Lys
• the endoprotease may be of microbial origin
• pyroglutamate formation occurs on terminal Gln of cleaved peptides
• on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58

Structure

• O-glycosylated

Compartment

secreted

Polymorphism

• the number of repeats is polymorphic & varies among different alleles

More general terms

• salivary proline-rich protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5542
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5542
• OMIM: https://mirror.omim.org/entry/180989
• UniProt: http://www.uniprot.org/uniprot/P04280.html