LRRK2 gene mutation
Jump to navigation
Jump to search
Clinical significance
- defects in LRRK2 are the cause of Parkinson disease 8 (PARK8)
- LRRK2 G2019S mutation carriers with milder progression of motor symptoms than idiopathic Parkinson's disease, but no difference in cognitive function[2]
More general terms
More specific terms
Additional terms
References
- ↑ Loinc
- ↑ 2.0 2.1 George J. Genetic Mutation Slows Motor Symptoms in PD. Research could inform trials of new anti-Parkinson's disease drugs. MedPage Today January 11, 2018 https://www.medpagetoday.com/neurology/parkinsonsdisease/70438
Saunders-Pullman R, Mirelman A, Alcalay RN et al Progression in the LRRK2-Asssociated Parkinson Disease Population. JAMA Neurol. Published online January 8, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29309488 https://jamanetwork.com/journals/jamaneurology/article-abstract/2668463