protein-lysine methyltransferase METTL21D; methyltransferase-like protein 21D; VCP lysine methyltransferase; VCP-KMT; Valosin-containing protein lysine methyltransferase (VCPKMT C14orf138 METTL21D)

Function

• protein-lysine N-methyltransferase
• specifically trimethylates 'Lys-315' of VCP/p97
  • This modification may decrease VCP ATPase activity
• interacts with ALKBH6
• interacts with ASPSCR1 & UBXN6
• interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation

Structure

• belongs to the methyltransferase superfamily, METTL21 family

Compartment

cytoplasm

Alternative splicing

named isoforms=5

More general terms

• methyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79609
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79609
• OMIM: https://mirror.omim.org/entry/615260
• UniProt: http://www.uniprot.org/uniprot/Q9H867.html