ethanolamine-phosphate phospho-lyase; alanine-glyoxylate aminotransferase 2-like 1 (ETNPPL, AGXT2L1)

Function

• catalyzes pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate & acetaldehyde

ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate

Cofactor: pyridoxal phosphate

Kinetic parameters:

• KM=680 uM for phosphoethanolamine (at pH 7.4)
• Vmax=1.46 umol/min/mg enzyme (at pH 7.4)

Structure

• homotetramer
• belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
• does not seem to possess aminotransferase activity

Compartment

mitochondrion (putative)

Alternative splicing

named isoforms=3

More general terms

• mitochondrial protein
• ammonia lyase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64850
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64850
• OMIM: https://mirror.omim.org/entry/614682
• UniProt: http://www.uniprot.org/uniprot/Q8TBG4.html