Casein kinase II subunit alpha 3; CK II alpha 3; Casein kinase II alpha 1 polypeptide pseudogene (CSNK2A3, CSNK2A1P)

Function

• probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine
• heterotetramer composed of two catalytic subunits (alpha chain &/or alpha' chain) & two regulatory subunits (beta chains) (putative)
• interacts with PML

ATP + a protein = ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily
• contains 1 protein kinase domain

Expression

• detected in blood platelets & megakaryocyte cell lines
• poorly expressed in lung
• highly expressed in lung tumor tissues

Pathology

• amplification-dependent oncogene; promotes cell proliferation & tumorigenesis by down-regulating expression of the tumor suppressor protein, PML
• may play a role in the pathogenesis of the lung cancer development & progression

More general terms

• enzyme catalytic subunit

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NEV1.html