doxylamine/pyridoxine (Diclegis, Bendectin)

Indications

• nausea/vomiting associated with pregnancy (morning sickness)
  • may not be as effective as previously reported

Dosage

• start 2 tablets at bedtime
• maximum dose 4 tablest/day
  • 1 tablet in the morning
  • 1 tablet at noon
  • 2 tables at bedtime

tablets must be taken on an empty stomach

Adverse effects

• drowsiness or sleepiness (may be severe)

Notes

• Bendectin was voluntarily pulled from the market in 1983 due to concerns about birth defects
  • those concerns later proved to be unfounded

More general terms

• pharmacologic combination

Components

• doxylamine (UniSom)
• pyridoxine (a vitamin B6)