drug interaction(s) of methotrexate with proton pump inhibitors
Jump to navigation
Jump to search
Drug interactions
- proton pump inhibitors may increase methotrexate levels by inhibiting its renal clearance[1]
- risk is with high-dose methotrexate infusions
- problems might also occur with lower doses used for treatment of rheumatoid arthritis[1]
More general terms
References
- ↑ 1.0 1.1 1.2 Prescriber's Letter 19(12): 2012 Proton Pump Inhibitor-Methotrexate Interaction Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=281212&pb=PRL (subscription needed) http://www.prescribersletter.com