double homeobox protein 4C; DUX4c; double homeobox protein 4-like protein 9 (DUX4L9, DUX4C)

Function

• may be involved in transcriptional regulation
• may play a role in cell proliferation specifically in the process of muscle regeneration
• may interact with MYF5; regulates MYF5 expression

Structure

contains 2 homeobox DNA-binding domains

Compartment

nucleus

Expression

• expressed in myocytes (at protein level)
• up-regulated during myoblasts differentiation (at protein level)

Pathology

• up-regulated in myoblasts of facioscapulohumeral muscular dystrophy (FSHD) patients (at protein level)

More general terms

• double homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6RFH8.html