monoclonal antibody SAR2365535
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Indications
- dyslipidemia, with increased LDL cholesterol
- may be used with statin
Mechanism of action
- inhibits PCSK9
- decreases LDL cholesterol (50%)
More general terms
References
- ↑ Roth EM et al Atorvastatin with or without an Antibody to PCSK9 in Primary Hypercholesterolemia. N Engl J Med. Oct 31, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23113833 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1201832
- ↑ McKenney JM et al Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/ REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol. 2012 Jun 19;59(25):2344-53 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22463922