infantile-onset ascending spastic paralysis

Genetics

• associated with mutations in the gene for alsin

Clinical manifestations

• progressive spasticity & weakness of limbs

More general terms

• motor neuron disease
• genetic disease of the central nervous system

Additional terms

• alsin; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein (ALS2 ALS2CR6 KIAA1563)

Database

• OMIM: https://mirror.omim.org/entry/607225