thiopurine methyltransferase in erythrocytes
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Indications
- assessment of likelihood of adverse drug reaction (toxicity) from azathioprine or 6-mercaptopurine[2]
Laboratory
Clinical significance
- low thiopurine methyltransferase activity increases likelihood of bone marrow toxicity from azathioprine[2][4] or 6-mercaptopurine[2]
- prevalence by phenotype
- low activity: 0.3%*
- intermediate: 10%
- normal activity: 90%
- see ref[1] for genotypes
More general terms
Additional terms
References
- ↑ 1.0 1.1 1.2 ARUP Consult: Thiopurine Drug Therapy https://arupconsult.com/ati/thiopurine-drug-therapy
- ↑ 2.0 2.1 2.2 2.3 Medical Knowledge Self Assessment Program (MKSAP) 17, 18 American College of Physicians, Philadelphia 2015, 2018.
- ↑ TPMT Lab Tests Online: http://www.labtestsonline.org/understanding/analytes/tpmt/glance.html
- ↑ 4.0 4.1 4.2 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline information for azathioprine and TPMT. https://www.pharmgkb.org/guideline/PA166104933
Patient information
thiopurine methyltransferase in erythrocytes patient information