UGT1A1 genotyping

Indications

• irinotecan (in doses >150 mg/m2)
• history of irinotecan sensitivity
• neutropenia while receiving irinotecan
• patient suspected to have Gilbert syndrome
• prescription of atazanavir

Laboratory

• see ARUP & ARUP consult

Clinical significance

• 2 decreased function UGT1A1 alleles may be associated with jaundice in patients prescribed atazanavir
• neutropenia while receiving irinotecan

More general terms

• genotyping (allele testing)

More specific terms

• UGT1A1 gene allele 1
• UGT1A1 gene allele 2
• UGT1A1 gene allele 3
• UGT1A1 gene mutation

Additional terms

• irinotecan; camptothecin (Camptosar, Topotecin, Onivyde, CPT-11)
• UDP-glucuronosyltransferase-1A (UDPGT-1A, bilirubin-specific isozyme 1, HUG-BR1, UGT1A1, GNT1, UGT1)
• UDP-glucuronosyltransferase-1A in blood/tissue