warfarin sensitivity testing (CYP2C8, CYP2C9, CYP4F2, VKORC1)
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Indications
- initiating warfarin therapy
- history of unstable warfarin dosing
- risk for bleeding events while receiving warfarin therapy
Laboratory
Specimen
- lavender top, do not freeze
Procedure
- Invader<TM> Warfarin Sensitivity Molecular Assay
- detection of common allelic variants in cytochrome P450 2C9 & vitamin K epoxide reductase complex subunit-1 (VKORC1) genes, including CYP2C9*1, CYP2C9*2 (3608C>T), CYP2C9*3 (42614A>C) & VKORC1 -1639G>A
- utilizes polymerase chain reaction (PCR)
More general terms
More specific terms
References
- ↑ Warfarin Sensitivity Testing (CYP2C9 and VKORC1) Barnes Jewish Hospital Washington University in St Louis http://pathology.wustl.edu/patientcare/pdf/warfarin.pdf
- ↑ Mini Panel of 2 tests: CYP2C9 Allele 2 . CYP2C9 Gene Mutation Interpretation Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0051103.jsp
- ↑ 3.0 3.1 ARUP Consult: Warfarin Sensitivity (CYP2C8, CYP2C9, CYP4F2, VKORC1) Genotyping https://arupconsult.com/ati/warfarin-sensitivity-genotyping