hydroxyacyl-thioester dehydratase type 2, mitochondrial; HsHTD2; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (RPP14)

Function

• mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis

(3R)-hydroxyacyl-CoA <-> trans-2-enoyl-CoA +H2O
(3R)-hydroxyacyl-[acyl-carrier-protein] <->
trans-2-enoyl-[acyl-carrier-protein] + H2O

Structure

belongs to the HTD2 family

Compartment

mitochondria

Expression

• highly expressed in heart & liver
• expressed at lower levels in skeletal muscle, spleen, kidney & placenta

Notes

• produced by a bicistronic gene which also produces the RPP14 protein from an overlapping reading frame

More general terms

• hydro-lyase, hydratase or dehydratase
• mitochondrial protein

Additional terms

• Rpp14

Database

• UniProt: http://www.uniprot.org/uniprot/P86397.html