disease interaction(s) of major depression with anxiety disorder(s)

Pathology

• comorbidity of anxiety & major depression in the elderly predicts more severe & treatment-resistant disease than either alone

Clinical manifestations

• excessive or prolonged rumination about adverse events
• increased impulsivity

Radiology

• functional magnetic resonance imaging
  • excessive activity in the amygdala in response to affective stimuli

Management

• partial response to treatment of major depression with comorbid anxiety at 4 weeks increases the likelihood of full remission

More general terms

• disease interaction