serine/threonine protein kinase Nek4; never in mitosis A-related kinase 4; NimA-related protein kinase 4; serine/threonine protein kinase 2; serine/threonine protein kinase NRK2 (NEK4, STK2)

Function

• serine/threonine protein kinase
• seems to act exclusively upon threonine residues (Thr)

Structure

• belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
• contains 1 protein kinase domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• expression in adult heart > pancreas, skeletal muscle, brain, liver, kidney, lung & placenta
• present in most primary carcinomas

More general terms

• serine/threonine protein kinase NEK
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6787
• OMIM: https://mirror.omim.org/entry/601959
• UniProt: http://www.uniprot.org/uniprot/P51957.html