idiopathic generalized epilepsy
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Introduction
Includes the syndromes:
- juvenile absence epilepsy
- juvenile myoclonic epilepsy
- epilepsy with only generalized tonic-clonic seizures
Etiology
- genetic
- type 6 is polygenic & multifactorial
Epidemiology
- 1/3 of all epilepsy syndromes
Genetics
Clinical manifestations
- recurring generalized seizures in the absence of detectable brain lesions &/or metabolic abnormalities
- generalized seizures arise diffusely & simultaneously from both hemispheres of the brain
- tonic-clonic seizures, absence seizures or myoclonic seizures
- cognitive deficits[3]
- impulsivity
- personality disorder
- psychiatric disorder
- may be present 5 years prior to diagnosis[3]
Diagnostic procedures
- electroencephalogram may show generalised spike wave abnormality[2]
Radiology
- MRI neuroimaging generally normal[2]
More general terms
More specific terms
- epilepsy with grand mal seizures on awakening; epilepsy with only generalized tonic-clonic seizures
- juvenile absence epilepsy
- juvenile myoclonic epilepsy (of Janz)
References
- ↑ OMIM https://mirror.omim.org/entry/611942
- ↑ 2.0 2.1 2.2 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022 - ↑ 3.0 3.1 3.2 Gesche J, Rubboli G, Beier CP. Prodromal phase of idiopathic generalized epilepsy: A register-based case control study. Neurology 2024 Oct 22; 103:e209921. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39284111 https://www.neurology.org/doi/10.1212/WNL.0000000000209921