Laing early-onset distal myopathy
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Genetics
- autosomal dominant
- associated with defects in MYH7
Clinical manifestations
- differs from other distal myopathies in that onset is as early as 4 years of age
- selective weakness of the anterior tibial muscles is followed by weakness of the finger extensors & selected proximal muscle groups such as the hip abductors & rotators, the shoulder abductors & the sternocleidomastoids