thiopurine methyltransferase (TPMT) gene mutation

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Indications

Clinical significance

* low activity associated with greater risk of toxicity[2][3]

More general terms

Additional terms

References

  1. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline information for azathioprine and TPMT. https://www.pharmgkb.org/guideline/PA166104933
  2. 2.0 2.1 2.2 ARUP Laboratories: Thiopurine Methyltransferase Testing - TPMT. https://arupconsult.com/content/thiopurine-methyltransferase-testing
  3. 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018