drug interaction(s) of spironolactone with trimethoprim
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Drug interactions
- spironolactone in combination with trimethoprim (including trimethoprim/sulfamethoxazole) potentiates hyperkalemia in the elderly
- combination increases risk of sudden death in elderly[2]
More general terms
References
- ↑ Antoniou T et al. Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: Nested case-control study. BMJ 2011 Sep 12; 343:d5228 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21911446
- ↑ 2.0 2.1 Antoniou T et al. Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone. CMAJ 2015 Mar 3; 187:E138 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25646289 <Internet> http://www.cmaj.ca/content/187/4/E138