solute carrier family 4 member 11 (SLC4A11, sodium bicarbonate transporter-like protein 11, bicarbonate transporter-related protein 1, BTR1, Na+ borate cotransporter 1, NaBC1)

Function

• transporter involved in borate homeostasis
• in the absence of borate, it functions as a Na+ & OH-/H+ channel
• in the presence of borate functions as an electrogenic Na+ coupled borate cotransporter

Structure

• glycosylated
• belongs to the anion exchanger (TC 2.A.31) family

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highly expressed in kidney, testis, salivary gland, thyroid, trachea & corneal endothelium
• not detected in retina & lymphocytes

Pathology

• defects in SLC4A11 are the cause of
  • corneal dystrophy & perceptive deafness
  • corneal endothelial dystrophy type 2

More general terms

• transmembrane 10 protein
• glycoprotein
• solute carrier family 4 (SLC4, SLC4A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8395
• OMIM: https://mirror.omim.org/entry/217400
• OMIM: https://mirror.omim.org/entry/217700
• OMIM: https://mirror.omim.org/entry/610206
• UniProt: http://www.uniprot.org/uniprot/Q8NBS3.html