cytosolic acyl coenzyme A thioester hydrolase-like; acyl-CoA thioesterase 7-like (ACOT7L, BACHL)

Function

acyl-CoA thioesterase

palmitoyl-CoA + H2O <--> CoA + palmitate

Structure

• homodimer (probable)
• contains 2 acyl coenzyme A hydrolase domains

Compartment

cytoplasm (putative)

Expression

• expressed in all tissues examined

Pathology

• up-regulated in nasopharyngeal carcinoma (at protein level)
• genetic variations in ACOT7L may be a cause of susceptibility to nasopharyngeal carcinoma type 1 (NPCA1)
• a variant located in the regulatory region of the gene creates an AP1-binding site that significantly enhances binding of AP1 to the promoter, resulting in up-regulation in nasopharyngeal carcinoma

More general terms

• acyl-coenzyme A thioesterase

Database

• OMIM: https://mirror.omim.org/entry/607107
• OMIM: https://mirror.omim.org/entry/611963
• UniProt: http://www.uniprot.org/uniprot/Q6ZUV0.html