actin-related protein 3B; actin-like protein 3B; ARP3-beta; actin-related protein ARP4 (ACTR3B, ARP11, ARP4)

Function

• plays a role in the organization of the actin cytoskeleton
• may function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization & together with an activating nucleation-promoting factor (NPF)
• mediates the formation of branched actin networks
• may decrease metastatic potential of tumors
• interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC & ARPC5/p16-ARC

Structure

belongs to the actin family, ARP3 subfamily

Compartment

• cytoplasm, cytoskeleton (putative)
• cell projection (putative)

Alternative splicing

named isoforms=2

Expression

• detected in fetal brain
• detected throughout adult brain, in neurons from gray matter, but not in white matter
• detected in liver, skeletal muscle & pancreas
• detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P1U1.html