acyl-coenzyme A synthetase ACSM4, mitochondrial (ACSM4)

Function

• medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro)
• acts on fatty acids from C(4) to C(11) & on the corresponding 3-hydroxy- & 2,3- or 3,4-unsaturated fatty acids (in vitro)

ATP + an acid + CoA <--> AMP + diphosphate + an acyl-CoA

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

mitochondrial matrix (putative)

More general terms

• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0C7M7.html