lipid storage droplet protein 5 (LSDP5, PLIN5)
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Function
- binds to lipid droplets & protects them from lipolytic degradation
- enhances mitochondrial biogenesis & function
- fatty-acid-binding protein
- preferentially binds lipid droplet-derived monounsaturated fatty acids & traffics them to the nucleus following cAMP/PKA-mediated lipolytic stimulation
Structure
belongs to the perilipin family
Compartment
- lipid droplet, surface-associated
Alternative splicing
named isoforms=2
Expression
- expressed in skeletal muscle, liver, heart & kidney
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q00G26.html
- ↑ Najt CP, Khan SA, Heden TD et al Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. Mol Cell. 2020 Feb 20;77(4):810-824.e8. doi:http://dx.doi.org/ 10.1016/j.molcel.2019.12.003. Epub 2019 Dec 31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31901447