leprechaunism (Donohue syndrome)
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Genetics
- autosomal recessive
- associated with defects in insulin receptor (INSR)
Clinical manifestations
- most severe form of insulin resistance syndrome
- intrauterine & postnatal growth retardation
- death in early infancy
Laboratory
- serum glucose (high)
- serum insulin (high)
More general terms
- diabetes mellitus type 2 (insulin-resistant)
- genetic syndrome (multisystem disorder)
- genetic disease of the endocrine system